Modeling microelectrode biosensors: free-flow calibration can substantially underestimate tissue concentrations
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Modeling microelectrode biosensors: free-flow calibration can substantially underestimate tissue concentrations
Microelectrode amperometric biosensors are widely used to measure concentrations of analytes in solution and tissue including acetylcholine, adenosine, glucose, and glutamate. A great deal of experimental and modeling effort has been directed at quantifying the response of the biosensors themselves; however, the influence that the macroscopic tissue environment has on biosensor response has not...
متن کاملINNOVATIVE METHODOLOGY Modeling microelectrode biosensors: free-flow calibration can substantially underestimate tissue concentrations
Newton AJ, Wall MJ, Richardson MJ. Modeling microelectrode biosensors: free-flow calibration can substantially underestimate tissue concentrations. J Neurophysiol 117: 937–949, 2017. First published December 2, 2016; doi:10.1152/jn.00788.2016.—Microelectrode amperometric biosensors are widely used to measure concentrations of analytes in solution and tissue including acetylcholine, adenosine, g...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2017
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00788.2016